Full stack AI-powered
Next-generation
proteomics platform

Explore the technology

What we do

We measure, identify and quantify proteomes to find biomarkers that our partners can develop into diagnostic tests and novel drugs to improve health.
ProteIQ

Sources

Any sample type!

Deep proteome coverage

Deep proteome coverage. DIA-MS is highly multiplexed and compatible with virtually any biological sample containing proteins. It is capable of confidently and reproducibly identifying up to 11,000 proteins, the most of any proteomic technique

Low sample requirements

A single-shot analysis has low sample input requirements, making it highly cost-effective and especially useful in situations where sample availability is at a premium: for example when working with biopsies or primary cell cultures in clinical research.

High dynamic range

The extent of multiplexing is limited only by dynamic range, with up to 10⁵, DIA-MS demonstrates one of the highest dynamic ranges among single-shot methods.

Enrichments

Find and analyse any protein

Affinity purification
Immuno-
precipitation
Off-line fractionation
NP-MS

Fully adaptable platform, can be synergistically enhanced with quantitative post-translational modifications (PTM) characterization; with multi-shot analysis to increase the depth; with enrichments (IP-MS, AP-MS, NP-MS) to target specific proteins; or with the spiking of custom isotopically labelled standards to increase the confidence of identifications and enable absolute quantification.

Enzymatic Cleavage

Amplify the Confidence with better coverage

Low sample requirements

Tryptic digestion with a single enzyme is the gold standard for LC-MS proteomics, yet it lacks broad sequence coverage (on average < 5%) resulting in lower confidence of identification. We developed an automated, reproducible multi enzyme digestion approach (DIA-MED) which boosts the coverage and amplifies the confidence in your discoveries.

Data Acquisition

Unbiased, complete signal acquisition with DIA

Next-generation LC-MS

DIA-MS is a next-generation implementation of the gold standard in global proteome profiling.  In DIA-MS a complete picture of the proteome in the original sample is collected, and no data is lost or filtered out by the mass spectrometer.

Complete picture

All precursor ions are selected, by cycling successively through the determined region-of-interest

Robust identifications

Targets are clearly identifiable due to narrow isolation windows used in screening

High quantitative accuracy

Fragmented MS2 spectra of targets  deconvoluted for optimal quantitative performance

Complete picture

All precursor ions are selected, by cycling successively through the determined region-of-interest

Robust identifications

Targets are clearly identifiable due to narrow isolation windows used in screening

High quantitative accuracy

Fragmented MS2 spectra of targets  deconvoluted for optimal quantitative performance

Library generation

Identify more in a truly unbiased manner

Truly unbiased

Choose custom designed experimental libraries or comprehensive, truly unbiased in-silico analysis using ProteiQ's unique approach..

InfineQ

Get to insights faster, skip black boxes

Unparalleled speed to insights

Highly convoluted, multidimensional spectra data is processed with InfineQ™, our in-house developed proprietary AI-based bioinformatics pipeline, capable of delivering high-fidelity quantitative results for thousands of samples within minutes.

A unique opportunity at the cutting edge

A continually growing body of peer-reviewed literature firmly establishes confidence in DIA as a leading methodology in proteomic analysis. It is superior to older techniques such as DDA, which restricts data complexity at the expense of compromising reproducibility, throughput, and depth of coverage, a tradeoff now overcome by DIA. A large and innovative community is constantly working on improvements and developing new protocols, meaning that the efficiency and flexibility of DIA, along with its range of applications, will continue to grow in the future.

Contact us

Telephone:

+49 331 60118709

Address:

Am Muehlenberg 11, 14476
Potsdam, Germany

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