People associate proteins with food and muscle-building, but they perform a crucial role in all bodily functions - including sports performance and the immune system.

ProteiQ applies proteomics to measure, analyse and identify individual’s protein signatures as well as their changes which might affect performance.

Signaling cell
Signaling proteins
Target cell

Proteomics and Mass Spectrometry (MS)

Our central testing process uses proteomics based Mass Spectrometry, or ‘MS’ to measure the mass of molecules. Unlike most medical tests, which measure just one biomarker, MS allows us to measure hundreds of proteins, accurately and reproducibly, from just one dried blood spot.

The trick is to break the blood molecules into smaller particles, fragments, and measure their spectra. Only then can we analyse the output - ProteiQ’s integrated platform covers all the steps.

  • Blood
    sample
  • Protein
    extraction
  • Split
    to Peptides
  • Peptide separation & ionization
  • Precursor ions
  • Precursor
    selection
  • Fragmentation
    Collision
    Cell
  • Mass analyzer
    Orbitrap
  • MS2 spectrum
  • Quantification

ProteiQ uses two proteomics workflows:

The discovery proteomics workflow is used to identify which new proteins are involved in a biological process, for example, overreaching.

Once the biomarkers related to that process
have been identified and validated,
the second, targeted proteomics
workflow is applied. Here we target
only the proteins of specific interest

Discovery Proteomics

Dried blood spot proteome

Tryptic digestion

Proteotypic peptides

Measure as many
proteins as possible

Quantification and identification of proteins by searches against specific databases and libraries

Quantification and identification of proteins by targeted analysis

Targeted Proteomics

Dried blood spot proteome

Tryptic digestion

Proteotypic peptides

Target only those
proteins of interest

Quantification and identification of proteins by targeted analysis

Quantification and identification of proteins by targeted analysis

Data analysis of proteomics results

One dried blood spot generates around 1GB of data with over 6,000 identifiable particles and dozens of parameters.

The complexity of the data isn’t just because of the large number of proteins in your blood - your diet, fitness, genetic background and specific response to exercise all add to it.

ProteiQ develops algorithms and uses machine learning tools to interpret data to provide a comprehensive, individualised analysis to build personalised recommendations to improve your fitness.